261717-18-4
261717-18-4
Chemical Structure
MSX-2
- CAS No.: 261717-18-4
- Formula:C21H22N4O4
- Molecular Weight:394.42
IUPAC Name: (E)-3-(3-hydroxypropyl)-8-(3-methoxystyryl)-7-methyl-1-(prop-2-yn-1-yl)-3,7-dihydro-1H-purine-2,6-dione
InChIKey: FWLDDFYHEQMIGG-MDZDMXLPSA-N
SMILES: O=C(N(C1=C(C2=O)N(C(/C=C/C3=CC=CC(OC)=C3)=N1)C)CCCO)N2CC#C
Biological Activity: MSX-2 is A2A adenosine receptor antagonist, with Ki of 5 nM in human that plays an important role in Parkinson's disease[1][2].
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MSX-2 | 98.44% | MSX-2 is A2A adenosine receptor antagonist, with Ki of 5 nM in human that plays an important role in Parkinson's disease. | ||||||||||||||||||||
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References
- [1]. Manuel de Lera Ruiz, et al. Adenosine A2A Receptor as a Drug Discovery Target. J Med Chem. 2014 May 8;57(9):3623-50. [Content Brief]
- [2]. Tina Becic, et al. Growth factors FGF8 and FGF2 and their receptor FGFR1, transcriptional factors Msx-1 and MSX-2, and apoptotic factors p19 and RIP5 participate in the early human limb development. Acta Histochem. 2018 Apr;120(3):205-214. [Content Brief]
Keywords
