2669785-85-5
2669785-85-5
Chemical Structure
JPS036
- CAS No.: 2669785-85-5
- Formula:C51H66FN7O7S
- Molecular Weight:940.18
IUPAC Name: 3-(difluoromethyl)cyclobutane-1-carboxylic acid
InChIKey: NAADBQUVFJWCFU-XVYMMXEDSA-N
SMILES: O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=C(C=C(C4=C(N=CS4)C)C=C3)OCCCCCCCCCCCC(NC5=CC=C(C=C5)C(NC6=C(C=CC=C6)N)=O)=O)=O)=O
Biological Activity: JPS036 is a HDAC3 PROTAC degrader with a DC50 of 0.44 μM. JPS036 recruits the VHL E3 ligase to form a ternary complex with HDAC3, driving proteasome-mediated degradation. JPS036 is applicable to relevant research on colon cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JPS036 | 99.31% | JPS036 is a HDAC3 PROTAC degrader with a DC50 of 0.44 μM. JPS036 recruits the VHL E3 ligase to form a ternary complex with HDAC3, driving proteasome-mediated degradation. JPS036 is applicable to relevant research on colon cancer. | ||||||||||||||||||||
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References
Keywords
