268725-86-6
268725-86-6
Chemical Structure
CFM 1571
- CAS No.: 268725-86-6
- Formula:C23H28N4O3
- Molecular Weight:408.49
IUPAC Name: 1-benzyl-3-(3-(dimethylamino)propoxy)-N-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide
InChIKey: YZCSJBGQLATPMH-UHFFFAOYSA-N
SMILES: O=C(C1=CC(OCCCN(C)C)=NN1CC2=CC=CC=C2)NC3=CC=C(C=C3)OC
Biological Activity: CFM 1571 is a soluble guanylyl cyclase (sGC) activator with an IC50 of ~5.5 μM. CFM 1571 activates sGC in a NO-independent manner and exerts a synergistic effect with NO. CFM 1571 inhibits platelet aggregation[1][2].
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CFM 1571 | CFM 1571 is a soluble guanylyl cyclase (sGC) activator with an IC50 of ~5.5 μM. CFM 1571 activates sGC in a NO-independent manner and exerts a synergistic effect with NO. CFM 1571 inhibits platelet aggregation. | |||||||||||||||||||||
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References
- [1]. Evgenov OV, et al. NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov. 2006 Sep;5(9):755-68. [Content Brief]
- [2]. Jackson EB Jr, et al. Pharmacologic modulators of soluble guanylate cyclase/cyclic guanosine monophosphate in the vascular system - from bench top to bedside. Curr Vasc Pharmacol. 2007;5(1):1-14. [Content Brief]
Keywords
