2727088-38-0
2727088-38-0
Chemical Structure
5-HT6 inverse agonist 1
- CAS No.: 2727088-38-0
- Formula:C22H22Cl2FN3O3S
- Molecular Weight:498.40
InChIKey: BMXRLOAUNYHEAQ-UHFFFAOYSA-N
SMILES: O=C(NC1CCNCC1)C2=C(N(C=C2)S(=O)(C3=CC=CC(Cl)=C3)=O)C4=CC=C(C=C4)F.Cl
Biological Activity: 5-HT6 inverse agonist 1 (Compound 33) is an antagonist for 5-HT6 receptor with a Ki of 23 nM and a Kb of 6.62 nM. 5-HT6 inverse agonist 1 inhibits the 5-HT6R mediated Cdk5 and mTOR signaling pathway. 5-HT6 inverse agonist 1 reduces tactile hypersensitivity in spinal nerve ligation (SNL)-induced rat model[1].
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5-HT6 inverse agonist 1 | 5-HT6 inverse agonist 1 (Compound 33) is an antagonist for 5-HT6 receptor with a Ki of 23 nM and a Kb of 6.62 nM. 5-HT6 inverse agonist 1 inhibits the 5-HT6R mediated Cdk5 and mTOR signaling pathway. 5-HT6 inverse agonist 1 reduces tactile hypersensitivity in spinal nerve ligation (SNL)-induced rat model. | |||||||||||||||||||||
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References
Keywords
