2730151-31-0
Chemical Structure
PI3Kδ/γ-IN-3
- CAS No.: 2730151-31-0
- Formula:C23H20ClN9O
- Molecular Weight:473.92
IUPAC Name: 2,4-diamino-6-((2S,5S)-2-(5-chloro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl)-5-methylpyrrolidin-1-yl)pyrimidine-5-carbonitrile
InChIKey: WALAECWNQSIPAM-SJCJKPOMSA-N
SMILES: O=C1N(C2=CN=CC=C2)C([C@H]3N(C4=NC(N)=NC(N)=C4C#N)[C@H](CC3)C)=NC5=CC=CC(Cl)=C51
Biological Activity: PI3Kδ/γ-IN-3 (Compound 58) is a potent and orally active PI3Kδ and PI3Kγ dual inhibitor with IC50s of 1 nM and 16 nM, respectively. PI3Kδ/γ-IN-3 induces tumor cell apoptosis and can be used for B-cell malignancies research[1].
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PI3Kδ/γ-IN-3 | PI3Kδ/γ-IN-3 (Compound 58) is a potent and orally active PI3Kδ and PI3Kγ dual inhibitor with IC50s of 1 nM and 16 nM, respectively. PI3Kδ/γ-IN-3 induces tumor cell apoptosis and can be used for B-cell malignancies research. | |||||||||||||||||||||
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Keywords
