2748630-46-6
Chemical Structure
Flibanserin-d4 hydrochloride
Synonym(s): BIMT-17-d4 hydrochloride;BIMT-17BS-d4 hydrochloride
- CAS No.: 2748630-46-6
- Formula:C20H18D4ClF3N4O
- Molecular Weight:430.89
IUPAC Name: 1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl-1,1,2,2-d4)-1,3-dihydro-2H-benzo[d]imidazol-2-one hydrochloride
InChIKey: XGAGFLQFMFCIHZ-BMJFOILFSA-N
SMILES: O=C1NC2=CC=CC=C2N1C([2H])([2H])C([2H])([2H])N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3.Cl
Biological Activity: Flibanserin-d4 (BIMT-17-d4; BIMT-17BS-d4) hydrochloride is the d4-labeled Flibanserin hydrochloride (HY-A0095B). Flibanserin hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research[1]-[5].
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Flibanserin-d4 hydrochloride | Flibanserin-d4 (BIMT-17-d4; BIMT-17BS-d4) hydrochloride is the d4-labeled Flibanserin hydrochloride (HY-A0095B). Flibanserin hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research-. | |||||||||||||||||||||
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Flibanserin hydrochloride | Flibanserin (BIMT-17) hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research-. | |||||||||||||||||||||
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- [1]. Fayed M, et al. Insights into Flibanserin Oxidative Stress Degradation Pathway: In Silico – In Vitro Toxicity Assessment of Its Degradates[J]. New Journal of Chemistry, 2021.
- [5]. Gelman F, et al. Flibanserin for hypoactive sexual desire disorder: place in therapy. Ther Adv Chronic Dis. 2017 Jan;8(1):16-25. [Content Brief]
