Flibanserin-d4 hydrochloride
Flibanserin-d4 (BIMT-17-d4; BIMT-17BS-d4) hydrochloride is the d4-labeled Flibanserin hydrochloride (HY-A0095B). Flibanserin hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research-.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2748630-46-6
- 分子式: C20H18D4ClF3N4O
- 分子量:430.89
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
Ki: 1 nM (5-HT1A receptor); 49 nM (5-HT2A receptor)[2]
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 2748630-46-6
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非標識Cas 147359-76-0
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分子量 430.89
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分子式 C20H18D4ClF3N4O
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SMILES
O=C1NC2=CC=CC=C2N1C([2H])([2H])C([2H])([2H])N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3.Cl
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別名
BIMT-17-d4 hydrochloride; BIMT-17BS-d4 hydrochloride
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[2]. Invernizzi RW, et al. A potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors. Br J Pharmacol. 2003 Aug;139(7):1281-8. [Content Brief]
[3]. Gelez H, et al. Brain neuronal activation induced by flibanserin treatment in female rats. Psychopharmacology (Berl). 2013 Dec;230(4):639-52. [Content Brief]
[4]. Podhorna J, et al. Flibanserin has anxiolytic effects without locomotor side effects in the infant rat ultrasonic vocalization model of anxiety. Br J Pharmacol. 2000 Jun;130(4):739-46. [Content Brief]
[5]. Gelman F, et al. Flibanserin for hypoactive sexual desire disorder: place in therapy. Ther Adv Chronic Dis. 2017 Jan;8(1):16-25. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Flibanserin-d4 hydrochloride 関連分類
HY-A0095AS 関連分類
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Keywords
- Flibanserin-d4
- 2748630-46-6
- BIMT-17-d4
- BIMT-17BS-d4
- Isotope-Labeled Compounds
- 5-HT Receptor
- Dopamine Receptor
- affinity
- neurotransmitter
- hypoactive
- sexual
- desire
- disorder
- antidepressant
- antianxiety
- hypoactive sexual desire disorder
- HSDD
- orally active
- DP1
- DP2
- no cytotoxicity
- NHSF cell line
- prefrontal cortex
- hippocampus
- midbrain
- Inhibitor
- inhibitor
- inhibit