147359-76-0
Chemical Structure
Flibanserin hydrochloride
Synonym(s): BIMT-17 hydrochloride; BIMT-17BS hydrochloride
- CAS No.: 147359-76-0
- Formula:C20H22ClF3N4O
- Molecular Weight:426.86
InChIKey: XGAGFLQFMFCIHZ-UHFFFAOYSA-N
SMILES: O=C1NC2=C(N1CCN3CCN(CC3)C4=CC=CC(C(F)(F)F)=C4)C=CC=C2.Cl
Biological Activity: Flibanserin (BIMT-17) hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research[1]-[5].
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Flibanserin hydrochloride | Flibanserin (BIMT-17) hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research-. | |||||||||||||||||||||
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Flibanserin-d4 hydrochloride | Flibanserin-d4 (BIMT-17-d4; BIMT-17BS-d4) hydrochloride is the d4-labeled Flibanserin hydrochloride (HY-A0095B). Flibanserin hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research-. | |||||||||||||||||||||
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References
- [1]. Fayed M, et al. Insights into Flibanserin Oxidative Stress Degradation Pathway: In Silico – In Vitro Toxicity Assessment of Its Degradates[J]. New Journal of Chemistry, 2021.
- [5]. Gelman F, et al. Flibanserin for hypoactive sexual desire disorder: place in therapy. Ther Adv Chronic Dis. 2017 Jan;8(1):16-25. [Content Brief]
