2757498-74-9
2757498-74-9
Chemical Structure
ER covalent antagonist-1
- CAS No.: 2757498-74-9
- Formula:C33H32N2O5S
- Molecular Weight:568.68
InChIKey: RQHPVIVCSOSYLP-JXMROGBWSA-N
SMILES: O=C(C1=CC=CC=C1)C(SC2=CC(O)=CC=C23)=C3OC4=CC=C(C=C4)OC5CN(C5)C/C=C/C(N6CCCCC6)=O
Biological Activity: ER covalent antagonist-1 (Compound 39D) is the antagonist for estrogen receptor α (ERα). ER covalent antagonist-1 inhibits the proliferation of ERα-positive cell MCF-7 with an IC50 of 0.98 μM, arrests the cell cycle at G0/G1 phase, and induces apoptosis. ER covalent antagonist-1 exhibits antitumor efficacy in mouse model[1].
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ER covalent antagonist-1 | ER covalent antagonist-1 (Compound 39D) is the antagonist for estrogen receptor α (ERα). ER covalent antagonist-1 inhibits the proliferation of ERα-positive cell MCF-7 with an IC50 of 0.98 μM, arrests the cell cycle at G0/G1 phase, and induces apoptosis. ER covalent antagonist-1 exhibits antitumor efficacy in mouse model. | |||||||||||||||||||||
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