2760247-27-4

PROTAC SMARCA2 degrader-26 Chemical Structure
2760247-27-4

Chemical Structure

PROTAC SMARCA2 degrader-26

  • CAS No.: 2760247-27-4
  • Formula:C46H54N8O5S
  • Molecular Weight:831.04

InChIKey: XIXRYWFQUASWJN-NVWSSHRHSA-N

SMILES: OC(C=CC=C1)=C1C2=CC(C(C=C3)=CC=C3NC(CC4)CCN4CC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(N=CS7)C)C=C6)C)=O)=O)=O)=CN=N2

Biological Activity: PROTAC SMARCA2 degrader-26 (compound 45) is a potent SMARCA2 PROTAC degrader. PROTAC SMARCA2 degrader-26 induces SMARCA2 and SMARCA4 degradation in VCaP cells with the percent degradation of 94% and 57% for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2 degrader-26 shows antiproliferative activity[1].

Cat. No. Product Name Purity Description Pricing
HY-169278 		PROTAC SMARCA2 degrader-26 PROTAC SMARCA2 degrader-26 (compound 45) is a potent SMARCA2 PROTAC degrader. PROTAC SMARCA2 degrader-26 induces SMARCA2 and SMARCA4 degradation in VCaP cells with the percent degradation of 94% and 57% for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2 degrader-26 shows antiproliferative activity.
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