2767443-78-5
2767443-78-5
Chemical Structure
NBTIs-IN-5
- CAS No.: 2767443-78-5
- Formula:C24H25F3N4O2
- Molecular Weight:458.48
IUPAC Name: (1r,4r)-N-(6-methoxy-1,5-naphthyridin-4-yl)-4-((4-(trifluoromethyl)benzyl)amino)cyclohexane-1-carboxamide
InChIKey: HYPVIZDRHBBZPJ-SAABIXHNSA-N
SMILES: COC1=CC=C2N=CC=C(C2=N1)NC([C@H]3CC[C@@H](CC3)NCC4=CC=C(C=C4)C(F)(F)F)=O
Biological Activity: NBTIs-IN-5 (Compound 5r) is a NBTI (Novel Bacterial Topoisomerase Inhibitor) DNA gyrase inhibitor with an IC50 of 1.5 μM against Mycobacterium abscessus (Mabs) DNA gyrase. NBTIs-IN-5 inhibits Mabs bamboo bacterial growth with an MIC90 of 0.4 μM[1].
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NBTIs-IN-5 | NBTIs-IN-5 (Compound 5r) is a NBTI (Novel Bacterial Topoisomerase Inhibitor) DNA gyrase inhibitor with an IC50 of 1.5 μM against Mycobacterium abscessus (Mabs) DNA gyrase. NBTIs-IN-5 inhibits Mabs bamboo bacterial growth with an MIC90 of 0.4 μM. | |||||||||||||||||||||
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References
Keywords
