2769893-19-6
2769893-19-6
Chemical Structure
BET-IN-8
- CAS No.: 2769893-19-6
- Formula:C22H21N3O4S
- Molecular Weight:423.48
IUPAC Name: 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile
InChIKey: MWOWDHZENZTEKV-UHFFFAOYSA-N
SMILES: COC1=CC(C2=C(C(NC(SCC3=CC=CC=C3C)=N2)=O)C#N)=CC(OC)=C1OC
Biological Activity: BET-IN-8 (Compound 27) is a potent inhibitor of BET with a Ki and Kd of 0.83 and 0.571 μM, respectively. BET-IN-8 ameliorates LPS-induced sepsis in vivo. BET-IN-8 has the potential for the research of sepsis[1].
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BET-IN-8 | BET-IN-8 (Compound 27) is a potent inhibitor of BET with a Ki and Kd of 0.83 and 0.571 μM, respectively. BET-IN-8 ameliorates LPS-induced sepsis in vivo. BET-IN-8 has the potential for the research of sepsis. | |||||||||||||||||||||
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