2772700-36-2
Chemical Structure
β2AR agonist /M-receptor antagonist-1
- CAS No.: 2772700-36-2
- Formula:C33H40FN5O5S2
- Molecular Weight:669.83
IUPAC Name: (R)-7-(2-((2-fluoro-5-((4-(2-isopropylthiazole-5-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethyl)amino)-1-hydroxyethyl)-4-hydroxybenzo[d]thiazol-2(3H)-one
InChIKey: JJNJTYDTSPNGRC-SANMLTNESA-N
SMILES: O=C(C1=CN=C(C(C)C)S1)N2CC3(OCC2)CCN(CC3)CC4=CC(CCNC[C@@H](C5=C6C(NC(S6)=O)=C(C=C5)O)O)=C(C=C4)F
Biological Activity: β2AR agonist /M-receptor antagonist-1 is a potent dual muscarinic antagonist/beta 2 agonist (MABA). β2AR agonist /M-receptor antagonist-1 potently relaxes either Carbachol?(HY-B1208)-induced contraction, in the absence (MABA) or presence of Propranolol?(HY-B1208), or Histamine(HY-B1204)-induced contraction (β2)[1][2].
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β2AR agonist /M-receptor antagonist-1 | β2AR agonist /M-receptor antagonist-1 is a potent dual muscarinic antagonist/beta 2 agonist (MABA). β2AR agonist /M-receptor antagonist-1 potently relaxes either Carbachol?(HY-B1208)-induced contraction, in the absence (MABA) or presence of Propranolol?(HY-B1208), or Histamine(HY-B1204)-induced contraction (β2). | |||||||||||||||||||||
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References
- [1]. Huihui Ti, et al. Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). J Med Chem. 2019 Jul 11;62(13):5944-5978. [Content Brief]
- [2]. Fiorella Pastore, et al.In vitro pharmacological characterization of the novel inhaled bronchodilator CHF6366 acting as dual muscarinic antagonist/β2-agonist (MABA). European Respiratory Journal 2017 50: PA1805.
