2845104-25-6
Chemical Structure
PI3K/mTOR Inhibitor-11
- CAS No.: 2845104-25-6
- Formula:C27H21N7
- Molecular Weight:443.50
IUPAC Name: 2-methyl-2-(5-(2-methyl-8-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-imidazo[4,5-c]quinolin-1-yl)pyridin-2-yl)propanenitrile
InChIKey: JDUUUKXVZOZLSS-UHFFFAOYSA-N
SMILES: CC(C1=NC=C(N2C(C)=NC3=C2C4=CC(C5=CN=C(NC=C6)C6=C5)=CC=C4N=C3)C=C1)(C)C#N
Biological Activity: PI3K/mTOR Inhibitor-11 is an orally active PI3K/mTOR inhibitor (IC50: 3.5, 4.6, and 21.3 nM for PI3Kα, PI3Kδ, and mTOR). PI3K/mTOR Inhibitor-11 regulates the PI3K/AKT/mTOR signaling pathway by inhibiting the phosphorylation of AKT and S6 proteins. PI3K/mTOR Inhibitor-11 can be used in the research of cancers[1].
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PI3K/mTOR Inhibitor-11 | 99.65% | PI3K/mTOR Inhibitor-11 is an orally active PI3K/mTOR inhibitor (IC50: 3.5, 4.6, and 21.3 nM for PI3Kα, PI3Kδ, and mTOR). PI3K/mTOR Inhibitor-11 regulates the PI3K/AKT/mTOR signaling pathway by inhibiting the phosphorylation of AKT and S6 proteins. PI3K/mTOR Inhibitor-11 can be used in the research of cancers. | ||||||||||||||||||||
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Keywords
