2882975-84-8
2882975-84-8
Chemical Structure
PPARγ phosphorylation inhibitor 1
- CAS. Nr.: 2882975-84-8
- Formula:C22H14Cl2N2O4
- Molecular Weight:441.26
IUPAC Name: 3-(3,4-dichlorobenzyl)-4-oxo-6-phenoxy-3,4-dihydrophthalazine-1-carboxylic acid
InChIKey: IQKNCBUBONVBNJ-UHFFFAOYSA-N
SMILES: O=C(C1=NN(C(C2=C1C=CC(OC3=CC=CC=C3)=C2)=O)CC4=CC(Cl)=C(C=C4)Cl)O
Biological Activity: PPARγ phosphorylation inhibitor 1 (Compound 10) is a potent PPARγ binder with the IC50 of 24 nM. PPARγ phosphorylation inhibitor 1 inhibits CDK5-mediated phosphorylation of PPARγ Ser273 with the IC50 of 160 nM. PPARγ phosphorylation inhibitor 1 displays negligible PPARγ agonism in a reporter gene assay. Antidiabetic effects[1].
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PPARγ phosphorylation inhibitor 1 | 99.81% | PPARγ phosphorylation inhibitor 1 (Compound 10) is a potent PPARγ binder with the IC50 of 24 nM. PPARγ phosphorylation inhibitor 1 inhibits CDK5-mediated phosphorylation of PPARγ Ser273 with the IC50 of 160 nM. PPARγ phosphorylation inhibitor 1 displays negligible PPARγ agonism in a reporter gene assay. Antidiabetic effects. | ||||||||||||||||||||
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