2890177-94-1
2890177-94-1
Chemical Structure
AcrB-IN-3
- CAS No.: 2890177-94-1
- Formula:C30H33NO7
- Molecular Weight:519.59
IUPAC Name: 3-(3-((2,2-dimethyl-5-(morpholine-4-carbonyl)-3,4-dihydro-2H-benzo[h]chromen-7-yl)oxy)propoxy)benzoic acid
InChIKey: JMWQSOZOTRUQBD-UHFFFAOYSA-N
SMILES: O=C(C1=CC(OCCCOC2=CC=CC3=C2C=C(C(N4CCOCC4)=O)C5=C3OC(C)(CC5)C)=CC=C1)O
Biological Activity: Efflux pump-IN-3 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. Efflux pump-IN-3 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-3 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model[1].
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AcrB-IN-3 | Efflux pump-IN-3 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. Efflux pump-IN-3 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-3 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model. | |||||||||||||||||||||
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