2892824-25-6
2892824-25-6
Chemical Structure
BDM88855
- CAS No.: 2892824-25-6
- Formula:C13H14ClN3
- Molecular Weight:247.72
InChIKey: JJZVQFQJCHXCFQ-UHFFFAOYSA-N
SMILES: ClC1=C(N2CCNCC2)N=C(C=CC=C3)C3=C1
Biological Activity: BDM88855 is an allosteric inhibitor for the homolog AcrB protein. BDM88855 can boost the antibacterial effect of a panel of antibiotics (eg: Oxacillin (HY-B0925A), Linezolid (HY-10394), Novobiocin (HY-B0425), etc.) on wild-type E. coli[1][2].
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BDM88855 | BDM88855 is an allosteric inhibitor for the homolog AcrB protein. BDM88855 can boost the antibacterial effect of a panel of antibiotics (eg: Oxacillin (HY-B0925A), Linezolid (HY-10394), Novobiocin (HY-B0425), etc.) on wild-type E. coli. | |||||||||||||||||||||
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References
- [1]. Plé C, et al. Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nat Commun. 2022 Jan 10;13(1):115. [Content Brief]
- [2]. Bera A, et al. Exploring transmembrane allostery in the MexB: DB08385 variant as a promising inhibitor-like candidate against Pseudomonas aeruginosa antibiotic resistance: a computational study. Phys [Content Brief]
Keywords
