2923223-81-6
Chemical Structure
TNG917
- CAS No.: 2923223-81-6
- Formula:C20H24FN5O
- Molecular Weight:369.44
InChIKey: CWXINBHXLZCNHE-UHFFFAOYSA-N
SMILES: FC(C(C1=CCNCCC1)=C2OCCC2=C3)=C3NC4=NC(C)=CC(NC)=N4
Biological Activity: TNG917 is a potent, selective EHMT1/2 inhibitor with oral activity. TNG917 reduces H3K9me2-mediated transcriptional repression, restores interferon-stimulated gene expression, promotes the secretion of T-cell chemokines such as CXCL10, and converts immunologically cold tumors into T-cell inflamed tumors. TNG917 is applicable to studies on immunologically cold tumors, colorectal cancer, anti-tumor immunity, interferon signaling pathways and epigenetic immune escape[1][2].
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TNG917 | TNG917 is a potent, selective EHMT1/2 inhibitor with oral activity. TNG917 reduces H3K9me2-mediated transcriptional repression, restores interferon-stimulated gene expression, promotes the secretion of T-cell chemokines such as CXCL10, and converts immunologically cold tumors into T-cell inflamed tumors. TNG917 is applicable to studies on immunologically cold tumors, colorectal cancer, anti-tumor immunity, interferon signaling pathways and epigenetic immune escape. | |||||||||||||||||||||
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- [1]. Lu A, et al. TNG917 is a clinical-grade, potent and selective inhibitor of EHMT1/2 for the treatment of immune cold tumors. Poster Abstract 3242. 2024.
- [2]. Lu AZ, et al. TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Anti-Tumor Immunity and Immunotherapy Efficacy. Cancer research. 2026 Jun 10. [Content Brief]
Keywords
