2951100-44-8
2951100-44-8
Chemical Structure
ATX inhibitor 25
- CAS No.: 2951100-44-8
- Formula:C23H20ClFN4O5
- Molecular Weight:486.88
InChIKey: CZTMIUXPPORYOV-UHFFFAOYSA-N
SMILES: CC1=C(C(NC2=CC(C(O)=O)=C(F)C=C2)=O)C3=CC(OC)=C(Cl)C=C3N1C4=CN(COC)N=C4
Biological Activity: ATX inhibitor 25 (Compound 29) is an orally active Autotaxin inhibitor with an IC50 of 1.08 nM. ATX inhibitor 25 exhibits excellent in vitro metabolic stability, with a t1/2 of more than 170 minutes. In the bleomycin (HY-108345)-induced pulmonary fibrosis mouse model, orally administered ATX inhibitor 25 shows anti-fibrotic effects[1].
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ATX inhibitor 25 | ATX inhibitor 25 (Compound 29) is an orally active Autotaxin inhibitor with an IC50 of 1.08 nM. ATX inhibitor 25 exhibits excellent in vitro metabolic stability, with a t1/2 of more than 170 minutes. In the bleomycin (HY-108345)-induced pulmonary fibrosis mouse model, orally administered ATX inhibitor 25 shows anti-fibrotic effects. | |||||||||||||||||||||
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References
Keywords
