299900-84-8
Chemical Structure
YM-202074 fumarate
- CAS No.: 299900-84-8
- Formula:C56H72N8O16S2
- Molecular Weight:1177.34
IUPAC Name: N-cyclohexyl-6-(((2-methoxyethyl)(methyl)amino)methyl)-N-methylbenzo[4,5]imidazo[2,1-b]thiazole-2-carboxamide sesquifumarate
InChIKey: HABHEZNVNBKOQJ-VQYXCCSOSA-N
SMILES: OC(/C=C/C(O)=O)=O.CN(C1CCCCC1)C(C2=CN3C4=CC(CN(C)CCOC)=CC=C4N=C3S2)=O.OC(/C=C/C(O)=O)=O.OC(/C=C/C(O)=O)=O.CN(C5CCCCC5)C(C6=CN7C8=CC(CN(C)CCOC)=CC=C8N=C7S6)=O
Biological Activity: YM-202074 fumarate is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 fumarate binds to the allosteric site of rat mGluR1 with a Ki of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 8.6 nM. YM-202074 fumarate has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models[1].
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YM-202074 fumarate | YM-202074 fumarate is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 fumarate binds to the allosteric site of rat mGluR1 with a Ki of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 8.6 nM. YM-202074 fumarate has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models. | |||||||||||||||||||||
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Keywords
