3035638-40-2
3035638-40-2
Chemical Structure
MS15
- CAS 番号: 3035638-40-2
- Formula:C64H79N11O5S
- Molecular Weight:1114.45
IUPAC Name: (Z)-3-((tert-butylamino)methylene)naphthalene-1,2,4(3H)-trione
InChIKey: XYGBNRINQSQNJG-IQDHSYJRSA-N
SMILES: NC1(CCC1)C(C=C2)=CC=C2N3C4=NC(C5=CC(CCC(NCCCCCCCCCCC(N[C@H](C(N6C[C@@H](C[C@H]6C(N[C@@H](C)C7=CC=C(C=C7)C8=C(N=CS8)C)=O)O)=O)C(C)(C)C)=O)=O)=CC=C5)=CC=C4N=C3C9=CC=CN=C9N
Biological Activity: MS15 is a potent and selective AKT PROTAC degrader. MS15 inhibits the AKT1, -2, and -3 activities, with IC50 values of 798 nM, 90 nM, and 544 nM, respectively[1].
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MS15 | MS15 is a potent and selective AKT PROTAC degrader. MS15 inhibits the AKT1, -2, and -3 activities, with IC50 values of 798 nM, 90 nM, and 544 nM, respectively. | |||||||||||||||||||||
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References
Keywords
