3046428-94-5
3046428-94-5
Chemical Structure
VEGFR-2-IN-52
- CAS No.: 3046428-94-5
- Formula:C20H25ClN4O2S
- Molecular Weight:420.96
InChIKey: HWTBGMPPWMANLH-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C2=CSC(NC(NCCCCN3CCCC3)=O)=C2C(N)=O)C=C1
Biological Activity: VEGFR-2-IN-52 (compound 14d) is a potent VEGFR-2 inhibitor with an IC50 value of 191.1 nM. VEGFR-2-IN-52 decreases the protein expression of p-VEGFR-2, MMP9, p-ERK1/2 and p-MEK1. VEGFR-2-IN-52 shows cytotoxicity. VEGFR-2-IN-52 induces apoptosis and cell cycle arrest at G0/G1 phase. VEGFR-2-IN-52 increases the levels of ROS[1].
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VEGFR-2-IN-52 | VEGFR-2-IN-52 (compound 14d) is a potent VEGFR-2 inhibitor with an IC50 value of 191.1 nM. VEGFR-2-IN-52 decreases the protein expression of p-VEGFR-2, MMP9, p-ERK1/2 and p-MEK1. VEGFR-2-IN-52 shows cytotoxicity. VEGFR-2-IN-52 induces apoptosis and cell cycle arrest at G0/G1 phase. VEGFR-2-IN-52 increases the levels of ROS. | |||||||||||||||||||||
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References
Keywords
