304896-21-7
Chemical Structure
AGK7
Synonym(s): SIRT2 Inhibitor,Inactive Control
- CAS No.: 304896-21-7
- Formula:C23H13Cl2N3O2
- Molecular Weight:434.27
IUPAC Name: (E)-2-cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-8-yl)acrylamide
InChIKey: WRDKBSLEHFRKGG-RVDMUPIBSA-N
SMILES: O=C(NC1=CC=CC2=C1N=CC=C2)/C(C#N)=C/C3=CC=C(O3)C4=CC(Cl)=CC=C4Cl
Biological Activity: AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease[1].
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AGK7 | AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. | |||||||||||||||||||||
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Keywords
