3049710-19-9
Chemical Structure
Factor B-IN-8
- CAS No.: 3049710-19-9
- Formula:C24H25F3N2O4
- Molecular Weight:462.46
InChIKey: PLAYMXKTNUBWPC-RBUKOAKNSA-N
SMILES: CC(C=C1OC)=C(NC=C2)C2=C1O[C@H]3[C@H](C4=CC=C(C=C4)C(O)=O)CN(CC3)CC(F)(F)F
Biological Activity: Factor B-IN-8 (Compound (3R ,4R )-15) is a potent, selective and orally active factor B inhibitor with an IC50 of 10.2 nM. Factor B-IN-8 can effectively inhibit the binding of factor B to C3b and the subsequent formation of C3 convertase (C3bBb). Factor B-IN-8 can inhibit the deposition of membrane attack complex (MAC) mediated by alternativepathway with an IC50 of 59.3 nM. Factor B-IN-8 can reduce the cleavage of factor B protein and decrease the deposition of complement C3d in the glomeruli and renal tubules. Factor B-IN-8 can be used for researches of arthritis and paroxysmal nocturnal hemoglobinuria (PNH)[1].
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Factor B-IN-8 | Factor B-IN-8 (Compound (3R ,4R )-15) is a potent, selective and orally active factor B inhibitor with an IC50 of 10.2 nM. Factor B-IN-8 can effectively inhibit the binding of factor B to C3b and the subsequent formation of C3 convertase (C3bBb). Factor B-IN-8 can inhibit the deposition of membrane attack complex (MAC) mediated by alternativepathway with an IC50 of 59.3 nM. Factor B-IN-8 can reduce the cleavage of factor B protein and decrease the deposition of complement C3d in the glomeruli and renal tubules. Factor B-IN-8 can be used for researches of arthritis and paroxysmal nocturnal hemoglobinuria (PNH). | |||||||||||||||||||||
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Keywords
