2. Immunology/Inflammation
  3. Complement System
  4. Factor B-IN-8

Factor B-IN-8 (Compound (3R ,4R )-15) is a potent, selective and orally active factor B inhibitor with an IC50 of 10.2 nM. Factor B-IN-8 can effectively inhibit the binding of factor B to C3b and the subsequent formation of C3 convertase (C3bBb). Factor B-IN-8 can inhibit the deposition of membrane attack complex (MAC) mediated by alternativepathway with an IC50 of 59.3 nM. Factor B-IN-8 can reduce the cleavage of factor B protein and decrease the deposition of complement C3d in the glomeruli and renal tubules. Factor B-IN-8 can be used for researches of arthritis and paroxysmal nocturnal hemoglobinuria (PNH).

For research use only. We do not sell to patients.

Factor B-IN-8

Factor B-IN-8 Chemical Structure

CAS No. : 3049710-19-9

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Description

Factor B-IN-8 (Compound (3R ,4R )-15) is a potent, selective and orally active factor B inhibitor with an IC50 of 10.2 nM. Factor B-IN-8 can effectively inhibit the binding of factor B to C3b and the subsequent formation of C3 convertase (C3bBb). Factor B-IN-8 can inhibit the deposition of membrane attack complex (MAC) mediated by alternativepathway with an IC50 of 59.3 nM. Factor B-IN-8 can reduce the cleavage of factor B protein and decrease the deposition of complement C3d in the glomeruli and renal tubules. Factor B-IN-8 can be used for researches of arthritis and paroxysmal nocturnal hemoglobinuria (PNH)[1].

Parmacokinetics
Species Dose Route T1/2 Cmax AUC0-t AUC0-∞ Vss Tmax F
Dog[1] 3 mg/kg i.v. 3.16 h 14947 ng/mL 8333 ng·h/mL 9487 ng·h/mL 1.23 L/kg / /
Dog[1] 6 mg/kg i.g. 5.83 h 4680 ng/mL 14388 ng·h/mL 16738 ng·h/mL / 0.46 h 86.77 %
Rat[1] 10 mg/kg i.v. 10.58 h 16788 ng/mL 11413 ng·h/mL 15313 ng·h/mL 9.18 L/kg / /
Rat[1] 20 mg/kg i.g. 9.28 h 2659 ng/mL 8793 ng·h/mL 13505 ng·h/mL / 0.38 h 51.82 %
Molecular Weight

462.46

Formula

C24H25F3N2O4
CAS No.
SMILES

CC(C=C1OC)=C(NC=C2)C2=C1O[C@H]3[C@H](C4=CC=C(C=C4)C(O)=O)CN(CC3)CC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Factor B-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Factor B-IN-83049710-19-9Complement SystemInhibitorinhibitorinhibit

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