3055032-68-0
3055032-68-0
Chemical Structure
WEE1/PKMYT1-IN-4
- CAS No.: 3055032-68-0
- Formula:C19H16FN5O2
- Molecular Weight:365.36
InChIKey: RZDINTIMXXVKTJ-UHFFFAOYSA-N
SMILES: CC1=C2NC(C(N)=C(C2=C(C=N1)OC3CC3)C4=C5C=NNC5=C(C=C4)F)=O
Biological Activity: WEE1/PKMYT1-IN-4 is a selective WEE1/PKMYT1 inhibitor, with IC50 values of 0.185 μM and 2.2 nM for human WEE1 and PKMYT1, respectively. WEE1/PKMYT1-IN-4 inhibits phosphorylation of CDK1 at T14 and Y15, disrupting the G2/M cell cycle checkpoint. WEE1/PKMYT1-IN-4 can be used for the research of colorectal cancer and amplified breast cancer[1].
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WEE1/PKMYT1-IN-4 | WEE1/PKMYT1-IN-4 is a selective WEE1/PKMYT1 inhibitor, with IC50 values of 0.185 μM and 2.2 nM for human WEE1 and PKMYT1, respectively. WEE1/PKMYT1-IN-4 inhibits phosphorylation of CDK1 at T14 and Y15, disrupting the G2/M cell cycle checkpoint. WEE1/PKMYT1-IN-4 can be used for the research of colorectal cancer and amplified breast cancer. | |||||||||||||||||||||
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References
Keywords
