3056618-93-7
Chemical Structure
PPARδ agonist 13
- CAS No.: 3056618-93-7
- Formula:C27H24F3N2NaO4
- Molecular Weight:520.48
InChIKey: ZYQJGYRDFINHDC-UHFFFAOYSA-M
SMILES: O=C(CCCCCOC1=C(CN2C(C3=CC=C(C=C3)OC(F)(F)F)=NC4=C2C=CC=C4)C=CC=C1)O[Na]
Biological Activity: PPARδ agonist 13 is a potent, selective and orally active PPARδ agonist with an EC50 values of 0.50 nM. PPARδ agonist 13 binds to the PPARδ ligand-binding pocket and upregulates PPARδ target gene expression. PPARδ agonist 13 inhibits renal fibroblast activation, restores fatty acid oxidation, and attenuates TGF-β1-induced renal fibroblast activation. PPARδ agonist 13 exhibits anti-renal fibrosis effects in a mouse model of unilateral ureteral obstruction. PPARδ agonist 13 can be used for the research of renal fibrosis[1].
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PPARδ agonist 13 | PPARδ agonist 13 is a potent, selective and orally active PPARδ agonist with an EC50 values of 0.50 nM. PPARδ agonist 13 binds to the PPARδ ligand-binding pocket and upregulates PPARδ target gene expression. PPARδ agonist 13 inhibits renal fibroblast activation, restores fatty acid oxidation, and attenuates TGF-β1-induced renal fibroblast activation. PPARδ agonist 13 exhibits anti-renal fibrosis effects in a mouse model of unilateral ureteral obstruction. PPARδ agonist 13 can be used for the research of renal fibrosis. | |||||||||||||||||||||
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Keywords
