3060504-68-6
3060504-68-6
Chemical Structure
GSPT1 degrader-16
- CAS No.: 3060504-68-6
- Formula:C36H30N6O5
- Molecular Weight:626.66
InChIKey: VRHAKFQIHFDVMX-SAEPALGJSA-N
SMILES: O=C(N/N=C/C1=NN(C2=C1C=CC=C2)CC3=CC=CC=C3)COC4=CC=CC=C4C5=C6C(C(N(C6)C7C(NC(CC7)=O)=O)=O)=CC=C5
Biological Activity: GSPT1 degrader-16 (Compound Lib-B-18J) is a potent and selective cereblon-based molecular glue degrader that targets G1 to S phase transition 1 (GSPT1). GSPT1 degrader-16 shows inhibitory effect to RS4;11, Molt4, and MM.1S cells with IC50 values of 0.002, 0.26 and 0.37 μM. GSPT1 degrader-16 can be used for the research of cancer, such as acute lymphoblastic leukemi[1].
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GSPT1 degrader-16 | GSPT1 degrader-16 (Compound Lib-B-18J) is a potent and selective cereblon-based molecular glue degrader that targets G1 to S phase transition 1 (GSPT1). GSPT1 degrader-16 shows inhibitory effect to RS4;11, Molt4, and MM.1S cells with IC50 values of 0.002, 0.26 and 0.37 μM. GSPT1 degrader-16 can be used for the research of cancer, such as acute lymphoblastic leukemi. | |||||||||||||||||||||
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