GSPT1 degrader-16
GSPT1 degrader-16 (Compound Lib-B-18J) is a potent and selective cereblon-based molecular glue degrader that targets G1 to S phase transition 1 (GSPT1). GSPT1 degrader-16 shows inhibitory effect to RS4;11, Molt4, and MM.1S cells with IC50 values of 0.002, 0.26 and 0.37 μM. GSPT1 degrader-16 can be used for the research of cancer, such as acute lymphoblastic leukemi.
For research use only. We do not sell to patients.
- CAS No.: 3060504-68-6
- Formula: C36H30N6O5
- Molecular Weight:626.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MM1.S | IC50 |
0.37 μM
Compound: Lib-B-18J; 18J
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Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
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[PMID: 37390512] |
| MOLT-4 | IC50 |
0.26 μM
Compound: Lib-B-18J; 18J
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Antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
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[PMID: 37390512] |
| RS4-11 | IC50 |
0.002 μM
Compound: Lib-B-18J; 18J
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Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
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[PMID: 37390512] |
Chemical Information
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CAS No. 3060504-68-6
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Molecular Weight 626.66
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Formula C36H30N6O5
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SMILES
O=C(N/N=C/C1=NN(C2=C1C=CC=C2)CC3=CC=CC=C3)COC4=CC=CC=C4C5=C6C(C(N(C6)C7C(NC(CC7)=O)=O)=O)=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSPT1 degrader-16 Related Classifications
HY-177765 Related Classifications
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