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  4. GSPT1 degrader-16

GSPT1 degrader-16 (Compound Lib-B-18J) is a potent and selective cereblon-based molecular glue degrader that targets G1 to S phase transition 1 (GSPT1). GSPT1 degrader-16 shows inhibitory effect to RS4;11, Molt4, and MM.1S cells with IC50 values of 0.002, 0.26 and 0.37 μM. GSPT1 degrader-16 can be used for the research of cancer, such as acute lymphoblastic leukemi.

For research use only. We do not sell to patients.

GSPT1 degrader-16

GSPT1 degrader-16 Chemical Structure

CAS No. : 3060504-68-6

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GSPT1 degrader-16 Related Antibodies

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Description

GSPT1 degrader-16 (Compound Lib-B-18J) is a potent and selective cereblon-based molecular glue degrader that targets G1 to S phase transition 1 (GSPT1). GSPT1 degrader-16 shows inhibitory effect to RS4;11, Molt4, and MM.1S cells with IC50 values of 0.002, 0.26 and 0.37 μM. GSPT1 degrader-16 can be used for the research of cancer, such as acute lymphoblastic leukemi[1].

Cellular Effect
Cell Line Type Value Description References
MM1.S IC50
0.37 μM
Compound: Lib-B-18J; 18J
Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
[PMID: 37390512]
MOLT-4 IC50
0.26 μM
Compound: Lib-B-18J; 18J
Antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
[PMID: 37390512]
RS4-11 IC50
0.002 μM
Compound: Lib-B-18J; 18J
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
[PMID: 37390512]
Molecular Weight

626.66

Formula

C36H30N6O5
CAS No.
SMILES

O=C(N/N=C/C1=NN(C2=C1C=CC=C2)CC3=CC=CC=C3)COC4=CC=CC=C4C5=C6C(C(N(C6)C7C(NC(CC7)=O)=O)=O)=CC=C5
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSPT1 degrader-16 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSPT1 degrader-163060504-68-6Molecular GluesGSPT1RS4;11Molt4and MM.1Sacute lymphoblastic leukemiacancerInhibitorinhibitorinhibit

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