3061154-57-9
3061154-57-9
Chemical Structure
SARS-CoV-2 Mpro-IN-34
- CAS No.: 3061154-57-9
- Formula:C30H37Cl2N5O3
- Molecular Weight:586.55
InChIKey: SZWKBXYVDYHRDG-AZGAKELHSA-N
SMILES: O=C([C@@H](CC1=C(Cl)C=C(Cl)C=C1)N(C(C[C@@H]2N3CC4(CC4)C2)=O)C)NCCCCCCNC5=CC(C3=O)=CN=C5
Biological Activity: SARS-CoV-2 Mpro-IN-34 (Compound 26) is an inhibitor for SARS-CoV-2 Mpro with an IC50 of 6 nM. SARS-CoV-2 Mpro-IN-34 exhibits inhibitory efficacy against OC43 Mpro with an IC50 of 33 nM. SARS-CoV-2 Mpro-IN-34 exhibits antiviral activity in SARS-CoV-2 infected Vero E6 cell with an EC50 of 0.103 μM[1].
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SARS-CoV-2 Mpro-IN-34 | SARS-CoV-2 Mpro-IN-34 (Compound 26) is an inhibitor for SARS-CoV-2 Mpro with an IC50 of 6 nM. SARS-CoV-2 Mpro-IN-34 exhibits inhibitory efficacy against OC43 Mpro with an IC50 of 33 nM. SARS-CoV-2 Mpro-IN-34 exhibits antiviral activity in SARS-CoV-2 infected Vero E6 cell with an EC50 of 0.103 μM. | |||||||||||||||||||||
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References
- [1]. Wang X, et al., Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants. J Med Chem. 2024 Nov 14;67(21):19623-19667. [Content Brief]
