SARS-CoV-2 Mpro-IN-34
SARS-CoV-2 Mpro-IN-34 (Compound 26) is an inhibitor for SARS-CoV-2 Mpro with an IC50 of 6 nM. SARS-CoV-2 Mpro-IN-34 exhibits inhibitory efficacy against OC43 Mpro with an IC50 of 33 nM. SARS-CoV-2 Mpro-IN-34 exhibits antiviral activity in SARS-CoV-2 infected Vero E6 cell with an EC50 of 0.103 μM.
For research use only. We do not sell to patients.
- Formula: C30H37Cl2N5O3
- Molecular Weight:586.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: SARS-CoV-2 Mpro (6 nM), OC43 Mpro (33 nM)
Chemical Information
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Molecular Weight 586.55
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Formula C30H37Cl2N5O3
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SMILES
O=C([C@@H](CC1=C(Cl)C=C(Cl)C=C1)N(C(C[C@@H]2N3CC4(CC4)C2)=O)C)NCCCCCCNC5=CC(C3=O)=CN=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wang X, et al., Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants. J Med Chem. 2024 Nov 14;67(21):19623-19667. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2 Mpro-IN-34 Related Classifications
HY-159961 Related Classifications
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