3069913-37-4
Chemical Structure
GSK-3β inhibitor 24
- CAS No.: 3069913-37-4
- Formula:C26H18N4O3
- Molecular Weight:434.45
InChIKey: URXDYCUBVFJMRC-UHFFFAOYSA-N
SMILES: O=C(C1=CNC2=NC=C(C3=CC=CC=C3)C=C21)NC4=C(C5=CC=C(OCO6)C6=C5)C=CN=C4
Biological Activity: GSK-3β inhibitor 24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. GSK-3β inhibitor 24 increases GSK-3β phosphorylation at Ser9 site dose-dependently. GSK-3β inhibitor 24 inhibits the hyperphosphorylation of tau protein by decreasing the p-tau-Ser396 abundance. GSK-3β inhibitor 24 up-regulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2). GSK-3β inhibitor 24 demonstrates remarkable anti-Alzheimer's disease (AD) effects[1].
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GSK-3β inhibitor 24 | GSK-3β inhibitor 24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. GSK-3β inhibitor 24 increases GSK-3β phosphorylation at Ser9 site dose-dependently. GSK-3β inhibitor 24 inhibits the hyperphosphorylation of tau protein by decreasing the p-tau-Ser396 abundance. GSK-3β inhibitor 24 up-regulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2). GSK-3β inhibitor 24 demonstrates remarkable anti-Alzheimer's disease (AD) effects. | |||||||||||||||||||||
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Keywords
