GSK-3β inhibitor 24
GSK-3β inhibitor 24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. GSK-3β inhibitor 24 increases GSK-3β phosphorylation at Ser9 site dose-dependently. GSK-3β inhibitor 24 inhibits the hyperphosphorylation of tau protein by decreasing the p-tau-Ser396 abundance. GSK-3β inhibitor 24 up-regulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2). GSK-3β inhibitor 24 demonstrates remarkable anti-Alzheimer's disease (AD) effects.
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- No. CAS: 3069913-37-4
- Fòrmula: C26H18N4O3
- Peso molecular:434.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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GSK-3β 0.22 nM (IC50) |
Chemical Information
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No. CAS 3069913-37-4
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Peso molecular 434.45
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Fòrmula C26H18N4O3
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SMILES
O=C(C1=CNC2=NC=C(C3=CC=CC=C3)C=C21)NC4=C(C5=CC=C(OCO6)C6=C5)C=CN=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK-3β inhibitor 24 Related Classifications
HY-168857 Related Classifications
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