3093763-27-7
3093763-27-7
Chemical Structure
CDK12 ligand-3
- CAS No.: 3093763-27-7
- Formula:C25H28ClN5O3S
- Molecular Weight:514.04
InChIKey: UDXXTSWRYRQIPG-LJQANCHMSA-N
SMILES: ClC1=CN=C(N[C@H]2CN(CCC2)C(C3=CC=CC=C3)=O)N=C1NC4=CC=CC=C4S(=O)(C(C)C)=O
Biological Activity: CDK12 ligand-3 is a monovalent CDK12/13 and cyclin K molecular glue degrader. CDK12 ligand-3 recruits DDB1, a core component of CUL4-based E3 ubiquitin ligase complexes, to drive ubiquitination and degradation of its targets[1].
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CDK12 ligand-3 | CDK12 ligand-3 is a monovalent CDK12/13 and cyclin K molecular glue degrader. CDK12 ligand-3 recruits DDB1, a core component of CUL4-based E3 ubiquitin ligase complexes, to drive ubiquitination and degradation of its targets. | |||||||||||||||||||||
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