3093938-66-7
Chemical Structure
SKL1223
- CAS No.: 3093938-66-7
- Formula:C19H15N3O2
- Molecular Weight:317.34
InChIKey: PWITXLYJAFNARC-UHFFFAOYSA-N
SMILES: C1(NCC2=CC=CO2)=CC=C(C=C1)C3=NC(C4=CC=CC=C4)=NO3
Biological Activity: SKL1223 is an orally effective thioredoxin-interacting protein (TXNIP) inhibitor with an IC50 of 0.64 µM. SKL1223 interacts with the E-box region of the TXNIP promoter to inhibit TXNIP transcription and related signaling pathways. SKL1223 reduces hepatic glucose output. SKL1223 exerts hypoglycemic effects by regulating the action of glucagon, and modulates blood glucose levels in Streptozotocin (HY-13753)-induced and obesity-induced diabetic mice. SKL1223 can be used in the research of type 1 diabetes and type 2 diabetes[1].
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SKL1223 | SKL1223 is an orally effective thioredoxin-interacting protein (TXNIP) inhibitor with an IC50 of 0.64 µM. SKL1223 interacts with the E-box region of the TXNIP promoter to inhibit TXNIP transcription and related signaling pathways. SKL1223 reduces hepatic glucose output. SKL1223 exerts hypoglycemic effects by regulating the action of glucagon, and modulates blood glucose levels in Streptozotocin (HY-13753)-induced and obesity-induced diabetic mice. SKL1223 can be used in the research of type 1 diabetes and type 2 diabetes. | |||||||||||||||||||||
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Keywords
