3099659-64-7
3099659-64-7
Chemical Structure
HDAC6 degrader-5
- CAS No.: 3099659-64-7
- Formula:C21H22N4O3
- Molecular Weight:378.42
InChIKey: JCPWBDUVBJFQSY-UHFFFAOYSA-N
SMILES: CCCC1=CC(C(NC2=CC=CC=C2)=O)=NN1CC3=CC=C(C=C3)C(NO)=O
Biological Activity: HDAC6 degrader-5 (Compound 6) exhibits inhibitory and degradation activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. HDAC6 degrader-5 inhibits the release of TNF-α, IL-1β and IL-6, blocks the hepatocyte apoptosis. HDAC6 degrader-5 exhibits anti-inflammatory activity in mouse APAP (HY-66005)-induced liver injury models[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
HDAC6 degrader-5 | 99.55% | HDAC6 degrader-5 (Compound 6) exhibits inhibitory and degradation activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. HDAC6 degrader-5 inhibits the release of TNF-α, IL-1β and IL-6, blocks the hepatocyte apoptosis. HDAC6 degrader-5 exhibits anti-inflammatory activity in mouse APAP (HY-66005)-induced liver injury models. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
