3105110-19-5
Chemical Structure
AChE/BuChE-IN-6
- CAS No.: 3105110-19-5
- Formula:C24H20ClN3O3
- Molecular Weight:433.89
InChIKey: RMGMKRLILJHZMN-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(Cl)C=C1)COC2=CC=C(O)C(C3=C(C4=CC=C(C)C=C4)NN=C3)=C2
Biological Activity: AChE/BuChE-IN-6 (Compound 11f) is an inhibitor of AChE and BuChE, with IC50 values of 1.24 and 1.85 μg/mL, respectively. AChE/BuChE-IN-6 also exhibits strong DPPH free radical scavenging activity (IC50 = 3.15 μg/mL). In vivo toxicity studies indicate that AChE/BuChE-IN-6 is safe, showing no significant differences in blood and biochemical markers compared to the control group after long-term administration, and no abnormalities were observed in liver and kidney tissues. AChE/BuChE-IN-6 holds promise for research into Alzheimer's disease[1].
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AChE/BuChE-IN-6 | AChE/BuChE-IN-6 (Compound 11f) is an inhibitor of AChE and BuChE, with IC50 values of 1.24 and 1.85 μg/mL, respectively. AChE/BuChE-IN-6 also exhibits strong DPPH free radical scavenging activity (IC50 = 3.15 μg/mL). In vivo toxicity studies indicate that AChE/BuChE-IN-6 is safe, showing no significant differences in blood and biochemical markers compared to the control group after long-term administration, and no abnormalities were observed in liver and kidney tissues. AChE/BuChE-IN-6 holds promise for research into Alzheimer's disease. | |||||||||||||||||||||
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