3106588-54-6
Chemical Structure
BRD4-BD1/2-IN-3
- CAS No.: 3106588-54-6
- Formula:C20H18N4O3
- Molecular Weight:362.38
IUPAC Name: 2-(1-benzyl-1H-pyrazol-4-yl)-5,7-dimethoxyquinazolin-4(3H)-one
InChIKey: LOVMUZHDFMMFBQ-UHFFFAOYSA-N
SMILES: O=C1NC(C2=CN(N=C2)CC3=CC=CC=C3)=NC4=CC(OC)=CC(OC)=C41
Biological Activity: BRD4-BD1/2-IN-3 (Compound B6) is a selective BRD4 BD2 inhibitor with an IC50 of 0.41 nM for BRD4 BD2 over BRD4 BD1. BRD4-BD1/2-IN-3 significantly inhibits the LPS (HY-D1056)-induced expression of IL-6. BRD4-BD1/2-IN-3 shows anti-inflammatory activities by modulating the TNF and NF-κB signaling pathway. BRD4-BD1/2-IN-3 can be used for inflammatory diseases research[1].
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BRD4-BD1/2-IN-3 | 99.52% | BRD4-BD1/2-IN-3 (Compound B6) is a selective BRD4 BD2 inhibitor with an IC50 of 0.41 nM for BRD4 BD2 over BRD4 BD1. BRD4-BD1/2-IN-3 significantly inhibits the LPS (HY-D1056)-induced expression of IL-6. BRD4-BD1/2-IN-3 shows anti-inflammatory activities by modulating the TNF and NF-κB signaling pathway. BRD4-BD1/2-IN-3 can be used for inflammatory diseases research. | ||||||||||||||||||||
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Keywords
