3108071-48-0
Chemical Structure
PROTAC NSD2 degrader-1
- CAS No.: 3108071-48-0
- Formula:C38H34N4O6
- Molecular Weight:642.70
InChIKey: YZNMZIWDILYEQP-UHFFFAOYSA-N
SMILES: O=C(N(C1CC1)CC2=CC=C(C(NC3=CC=C(CN(C(CC4=CC=C(C=O)C=C4)=O)CC5)C5=C3)=O)C=C2)C6=CC7=C(C=C6)NC(CO7)=O
Biological Activity: PROTAC NSD2 degrader-1 is a PROTAC degrader that selectively targets NSD2, with a DC50 of 0.37 μM. PROTAC NSD2 degrader-1 induces selective degradation of long and short isoforms of NSD2 containing the PWWP1 domain by forming a ternary complex with FBXO22. NSD2 degradation mediated by PROTAC NSD2 degrader-1 depends on the ubiquitin-proteasome system and the neddylation pathway. PROTAC NSD2 degrader-1 can be used in cancer-related research such as non-small cell lung cancer, multiple myeloma and prostate cancer[1].
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PROTAC NSD2 degrader-1 | PROTAC NSD2 degrader-1 is a PROTAC degrader that selectively targets NSD2, with a DC50 of 0.37 μM. PROTAC NSD2 degrader-1 induces selective degradation of long and short isoforms of NSD2 containing the PWWP1 domain by forming a ternary complex with FBXO22. NSD2 degradation mediated by PROTAC NSD2 degrader-1 depends on the ubiquitin-proteasome system and the neddylation pathway. PROTAC NSD2 degrader-1 can be used in cancer-related research such as non-small cell lung cancer, multiple myeloma and prostate cancer. | |||||||||||||||||||||
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Keywords
