3403-42-7
Chemical Structure
Methopromazine maleate
Synonym(s): Mopazine maleate
- CAS No.: 3403-42-7
- Formula:C22H26N2O5S
- Molecular Weight:430.52
IUPAC Name: 3-(2-methoxy-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine maleate
InChIKey: ZWLMLVIUWRUDBD-BTJKTKAUSA-N
SMILES: CN(C)CCCN1C2=CC(OC)=CC=C2SC3=CC=CC=C31.OC(/C=C\C(O)=O)=O
Biological Activity: Methopromazine maleate is a dopamine D2 receptor (Dopamine D2 receptor) antagonist belonging to the phenothiazine class of compounds, with an LD50 of 366 mg/kg in mouse studies. Methopromazine maleate competitively binds to and blocks G-protein coupled receptors (GPCR) in the central nervous system, thereby inhibiting downstream signal transduction. Methopromazine maleate can be used in research on chronic schizophrenia[1][2].
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Methopromazine maleate | Methopromazine maleate is a dopamine D2 receptor (Dopamine D2 receptor) antagonist belonging to the phenothiazine class of compounds, with an LD50 of 366 mg/kg in mouse studies. Methopromazine maleate competitively binds to and blocks G-protein coupled receptors (GPCR) in the central nervous system, thereby inhibiting downstream signal transduction. Methopromazine maleate can be used in research on chronic schizophrenia. | |||||||||||||||||||||
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- [1]. Esteki M, et al. Mechanistic-based descriptors for QSAR study of psychotropic drug toxicity. Chemical biology & drug design. 2008 Nov;72(5):409-35.
- [2]. BRADLEY PB, et al. The effect of chlorpromazine and methopromazine on the electrical activity of the brain in the cat. Electroencephalogr Clin Neurophysiol. 1957 May;9(2):191-215.
Keywords
