34435-05-7
Chemical Structure
C24-Ceramide
- CAS No.: 34435-05-7
- Formula:C42H83NO3
- Molecular Weight:650.11
IUPAC Name: N-((2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl)tetracosanamide
InChIKey: ZJVVOYPTFQEGPH-AUTSUKAISA-N
SMILES: CCCCCCCCCCCCCCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
Biological Activity: C24-Ceramide is an orally active competitive binding agonist of PIP4K2C (mTOR complex regulator), thereby activating the mTOR signaling pathway. At the same time, C24-Ceramide changes the membrane morphology by inducing the formation of a partially interlocked gel phase in the phospholipid bilayer. C24-Ceramide can promote the proliferation and migration of keratinocytes to accelerate skin wound healing and drive the proliferation and metastasis of gallbladder cancer cells. The level of C24-Ceramide in serum can be used as a diagnostic marker for gallbladder cancer[1][2][3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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C24-Ceramide | 99.92% | C24-Ceramide is an orally active competitive binding agonist of PIP4K2C (mTOR complex regulator), thereby activating the mTOR signaling pathway. At the same time, C24-Ceramide changes the membrane morphology by inducing the formation of a partially interlocked gel phase in the phospholipid bilayer. C24-Ceramide can promote the proliferation and migration of keratinocytes to accelerate skin wound healing and drive the proliferation and metastasis of gallbladder cancer cells. The level of C24-Ceramide in serum can be used as a diagnostic marker for gallbladder cancer. | ||||||||||||||||||||
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C24-Ceramide-d7 | 96.16% | C24-Ceramide-d7 is the deuterium labeled C24-Ceramide. | ||||||||||||||||||||
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References
- [1]. Ventura AE, et al. Lipid domain formation and membrane shaping by C24-ceramide. Biochim Biophys Acta Biomembr. 2020 Oct 1;1862(10):183400. [Content Brief]
- [2]. Lee JH, et al. C24 Ceramide Lipid Nanoparticles for Skin Wound Healing. Pharmaceutics. 2025 Feb 12;17(2):242. [Content Brief]
- [3]. Zhang Y, et al. C24-Ceramide Drives Gallbladder Cancer Progression Through Directly Targeting Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling Activation. Hepatology. 2021 Feb;73(2):692-712. [Content Brief]
