3482-37-9
Chemical Structure
Trimethylcolchicinic acid
Synonym(s): Desacetylcolchiceine; N-Deacetylcolchiceine
- CAS No.: 3482-37-9
- Formula:C19H21NO5
- Molecular Weight:343.37
IUPAC Name: (S)-7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one
InChIKey: IRVWPZRYDQROLU-ZDUSSCGKSA-N
SMILES: COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)N)=C3)=CC=C(O)C3=O
Biological Activity: Trimethylcolchicinic acid (Desacetylcolchiceine; N-Deacetylcolchiceine) is a colchicine analogue. Trimethylcolchicinic acid promotes the production of chondroitin sulfate in L cells and inhibits the production of dermatan sulfate. Trimethylcolchicinic acid reduces liver fibrosis and cholestasis induced by long-term biliary obstruction in rats. Trimethylcolchicinic acid has potential for use in research on diseases such as liver fibrosis, gout, and cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Trimethylcolchicinic acid | Trimethylcolchicinic acid (Desacetylcolchiceine; N-Deacetylcolchiceine) is a colchicine analogue. Trimethylcolchicinic acid promotes the production of chondroitin sulfate in L cells and inhibits the production of dermatan sulfate. Trimethylcolchicinic acid reduces liver fibrosis and cholestasis induced by long-term biliary obstruction in rats. Trimethylcolchicinic acid has potential for use in research on diseases such as liver fibrosis, gout, and cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Lorans G, et al. Effect of trimethylcolchicinic acid on the synthesis and excretion of proteoglycans in tissue culture. Eur J Biochem. 1975 Jan 15;50(3):563-9. [Content Brief]
- [2]. Muriel P, et al. Trimethylcolchicinic acid decreases liver fibrosis and cholestasis induced by prolonged biliary obstruction in the rat. J Appl Toxicol. 1997 May-Jun;17(3):145-51. [Content Brief]
- [3]. WALLACE SL. Trimethylcolchicinic acid in the treatment of acute gout. Ann Intern Med. 1961 Feb;54:274-9. [Content Brief]
Keywords
