Trimethylcolchicinic acid
Trimethylcolchicinic acid (Desacetylcolchiceine; N-Deacetylcolchiceine) is a colchicine analogue. Trimethylcolchicinic acid promotes the production of chondroitin sulfate in L cells and inhibits the production of dermatan sulfate. Trimethylcolchicinic acid reduces liver fibrosis and cholestasis induced by long-term biliary obstruction in rats. Trimethylcolchicinic acid has potential for use in research on diseases such as liver fibrosis, gout, and cancer.
For research use only. We do not sell to patients.
- CAS No.: 3482-37-9
- Formula: C19H21NO5
- Molecular Weight:343.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H9 | EC50 |
1.3 μM
Compound: 5
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Cytotoxicity against human H9 cells
Cytotoxicity against human H9 cells
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[PMID: 1919593] |
| H9 | IC50 |
1.2 μM
Compound: 5
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Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen capture assay
Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen capture assay
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[PMID: 1919593] |
Chemical Information
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CAS No. 3482-37-9
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Molecular Weight 343.37
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Formula C19H21NO5
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SMILES
COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)N)=C3)=CC=C(O)C3=O
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Synonyms
Desacetylcolchiceine; N-Deacetylcolchiceine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lorans G, et al. Effect of trimethylcolchicinic acid on the synthesis and excretion of proteoglycans in tissue culture. Eur J Biochem. 1975 Jan 15;50(3):563-9. [Content Brief]
[2]. Muriel P, et al. Trimethylcolchicinic acid decreases liver fibrosis and cholestasis induced by prolonged biliary obstruction in the rat. J Appl Toxicol. 1997 May-Jun;17(3):145-51. [Content Brief]
[3]. WALLACE SL. Trimethylcolchicinic acid in the treatment of acute gout. Ann Intern Med. 1961 Feb;54:274-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trimethylcolchicinic acid Related Classifications
HY-105526 Related Classifications
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