3608-58-0
Chemical Structure
3′-Deoxyguanosine
Synonym(s): Guanosine, 3'-deoxy-
- CAS No.: 3608-58-0
- Formula:C10H13N5O4
- Molecular Weight:267.25
IUPAC Name: 2-Amino-9-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
InChIKey: OROIAVZITJBGSM-OBXARNEKSA-N
SMILES: OC[C@@H]1C[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O1
Biological Activity: 3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a derivative of Guanosine (HY-N0097). 3′-Deoxyguanosine interacts with human purine nucleoside phosphorylase via hydrogen bonding with residues such as Glu201 and Asn243. 3′-Deoxyguanosine exhibits moderate displacement activity for [3H]-guanosine in rat meninges. 3′-Deoxyguanosine is useful for studying the mechanism of guanosine receptors and purine metabolism[1][2][3].
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3′-Deoxyguanosine | 97.0% | 3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a derivative of Guanosine (HY-N0097). 3′-Deoxyguanosine interacts with human purine nucleoside phosphorylase via hydrogen bonding with residues such as Glu201 and Asn243. 3′-Deoxyguanosine exhibits moderate displacement activity for [3H]-guanosine in rat meninges. 3′-Deoxyguanosine is useful for studying the mechanism of guanosine receptors and purine metabolism. | ||||||||||||||||||||
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- [1]. Traversa U, et al. Rat brain guanosine binding site. Biological studies and pseudo-receptor construction. Bioorg Med Chem. 2003 Dec 1;11(24):5417-25. [Content Brief]
- [2]. Canduri F, et al. Structure of human PNP complexed with ligands. Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):856-62. [Content Brief]
- [3]. King RW, et al. Inhibition of the replication of a hepatitis C virus-like RNA template by interferon and 3'-deoxycytidine. Antivir Chem Chemother. 2002 Nov;13(6):363-70. [Content Brief]
Keywords
