4025-59-6
Chemical Structure
5β,6β-Epoxycholestanol
Synonym(s): Cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol
- CAS No.: 4025-59-6
- Formula:C27H46O2
- Molecular Weight:402.65
IUPAC Name: (3S,4aS,5aR,6aS,6bS,9R,9aR,11aS,11bR)-9a,11b-dimethyl-9-((R)-6-methylheptan-2-yl)hexadecahydrocyclopenta[1,2]phenanthro[8a,9-b]oxiren-3-ol
InChIKey: PRYIJAGAEJZDBO-DTLXENBRSA-N
SMILES: C[C@]12[C@@]3(C[C@H](CC2)O)[C@](C[C@]4([H])[C@]1([H])CC[C@]5([C@@]4([H])CC[C@]5([H])[C@H](C)CCCC(C)C)C)([H])O3
Biological Activity: 5β,6β-epoxycholestanol (Cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol) is an oxysterol. 5β,6β-epoxycholestanol induces cytotoxicity in bronchial epithelial cells. 5β,6β-epoxycholestanol induces lactate dehydrogenase (LDH) release and apoptosis in lymphoma cells undergoing macrophage differentiation. 5β,6β-epoxycholestanol is applicable to research related to atherosclerosis[1][2][3].
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5β,6β-Epoxycholestanol | 98.0% | 5β,6β-epoxycholestanol (Cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol) is an oxysterol. 5β,6β-epoxycholestanol induces cytotoxicity in bronchial epithelial cells. 5β,6β-epoxycholestanol induces lactate dehydrogenase (LDH) release and apoptosis in lymphoma cells undergoing macrophage differentiation. 5β,6β-epoxycholestanol is applicable to research related to atherosclerosis. | ||||||||||||||||||||
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5β,6β-Epoxycholestanol-d7 | 99.0% | 5β,6β-Epoxycholestanol-d7 is deuterium labeled 5β,6β-Epoxycholestanol. | ||||||||||||||||||||
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- [1]. Pulfer MK, et al. Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant. J Biol Chem. 2004;279(25):26331-26338. [Content Brief]
- [2]. Aringer L, et al. Formation and metabolism in vitro of 5,6-epoxides of cholesterol and beta-sitosterol. J Lipid Res. 1974;15(4):389-398. [Content Brief]
- [3]. Garcia-Cruset S, et al. Oxysterol profiles of normal human arteries, fatty streaks and advanced lesions. Free Radic Res. 2001;35(1):31-41. [Content Brief]
