469-36-3
Chemical Structure
24-Methylenecycloartanyl ferulate
- CAS No.: 469-36-3
- Formula:C41H60O4
- Molecular Weight:616.91
IUPAC Name: (2aR,3R,5aS,5bS,7aR,9S,11aR)-2a,5a,8,8-tetramethyl-3-((R)-6-methyl-5-methyleneheptan-2-yl)tetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-9-yl (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate
InChIKey: JBSUVXVGZSMGDJ-CVXPGAKHSA-N
SMILES: CC1(C)[C@@H](OC(/C=C/C2=CC=C(O)C(OC)=C2)=O)CC[C@]3(C4)C54CC[C@]6(C)[C@@H]([C@H](C)CCC(C(C)C)=C)CC[C@](C)6[C@]5([H])CC[C@@]13[H]
Biological Activity: 24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive Akt1 inhibitor (EC50= 33.3μM)[1].
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24-Methylenecycloartanyl ferulate | 98.53% | 24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive Akt1 inhibitor (EC50= 33.3μM). | ||||||||||||||||||||
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- [1]. Heon Woong Kim, et al. 24-Methylenecycloartanyl ferulate, a major compound of γ-oryzanol, promotes parvin-beta expression through an interaction with peroxisome proliferator-activated receptor-gamma 2 in human breast cancer cells. Biochem Biophys Res Commun. 2015 Dec 25;468(4):574-9. [Content Brief]
Keywords
