581-49-7
Chemical Structure
(S)-(-)-Anatabine
- CAS No.: 581-49-7
- Formula:C10H12N2
- Molecular Weight:160.22
IUPAC Name: (S)-1,2,3,6-tetrahydro-2,3'-bipyridine
InChIKey: SOPPBXUYQGUQHE-JTQLQIEISA-N
SMILES: [C@@H]1(C2=CC=CN=C2)CC=CCN1
Biological Activity: (S)-(-)-Anatabine is an NFκB/BACE-1 inhibitor with blood-brain barrier penetration. (S)-(-)-Anatabine inhibits NFκB activation via phosphorylation of its p65 subunit. (S)-(-)-Anatabine inhibits BACE-1 transcription and reduces BACE-1 protein levels. (S)-(-)-Anatabine lowers production of Aβ1-40 and Aβ1-42 by reducing β-cleavage of amyloid precursor protein without affecting α-cleavage. (S)-(-)-Anatabine can be used for the research of Alzheimer's disease[1].
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(S)-(-)-Anatabine | (S)-(-)-Anatabine is an NFκB/BACE-1 inhibitor with blood-brain barrier penetration. (S)-(-)-Anatabine inhibits NFκB activation via phosphorylation of its p65 subunit. (S)-(-)-Anatabine inhibits BACE-1 transcription and reduces BACE-1 protein levels. (S)-(-)-Anatabine lowers production of Aβ1-40 and Aβ1-42 by reducing β-cleavage of amyloid precursor protein without affecting α-cleavage. (S)-(-)-Anatabine can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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Keywords
