59653-73-5
Chemical Structure
α-Triglycidyl isocyanurate
Synonym(s): Teroxirone
- CAS No.: 59653-73-5
- Formula:C12H15N3O6
- Molecular Weight:297.26
IUPAC Name: 1,3-bis(((R)-oxiran-2-yl)methyl)-5-(((S)-oxiran-2-yl)methyl)-1,3,5-triazinane-2,4,6-trione
InChIKey: OUPZKGBUJRBPGC-HLTSFMKQSA-N
SMILES: O=C(N(C(N(C1=O)C[C@H]2CO2)=O)C[C@@H]3CO3)N1C[C@@H]4CO4
Biological Activity: α-Triglycidyl isocyanurate (Teroxirone) is an antitumor compound with activity to inhibit DNA replication. α-Triglycidyl isocyanurate exerts its anticancer effect by alkylating and cross-linking DNA. α-Triglycidyl isocyanurate is relatively stable in fresh human plasma and whole blood, showing good biocompatibility. The metabolism of α-Triglycidyl isocyanurate mainly occurs in rat liver and is metabolized through an NADPH-independent pathway. The cytotoxicity of α-Triglycidyl isocyanurate can be partially restored under specific conditions, suggesting the complexity of its metabolic pathway[1].
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α-Triglycidyl isocyanurate | α-Triglycidyl isocyanurate (Teroxirone) is an antitumor compound with activity to inhibit DNA replication. α-Triglycidyl isocyanurate exerts its anticancer effect by alkylating and cross-linking DNA. α-Triglycidyl isocyanurate is relatively stable in fresh human plasma and whole blood, showing good biocompatibility. The metabolism of α-Triglycidyl isocyanurate mainly occurs in rat liver and is metabolized through an NADPH-independent pathway. The cytotoxicity of α-Triglycidyl isocyanurate can be partially restored under specific conditions, suggesting the complexity of its metabolic pathway. | |||||||||||||||||||||
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Keywords
