62404-82-4
62404-82-4
Chemical Structure
N-Mercaptoacetyl-L-histidine
- CAS No.: 62404-82-4
- Formula:C8H11N3O3S
- Molecular Weight:229.26
InChIKey: CSHODVSRCYFEOH-LURJTMIESA-N
SMILES: SCC(N[C@H](C(O)=O)CC1=CN=CN1)=O
Biological Activity: N-Mercaptoacetyl-L-histidine is an angiotensin-converting enzyme (ACE) inhibitor with a target pIC50 of 3.59 M.N-Mercaptoacetyl-L-histidine binds to the zinc-containing active site of ACE, which mediates conversion of angiotensin I to angiotensin II.N-Mercaptoacetyl-L-histidine can be used for the research of hypertension[1].
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N-Mercaptoacetyl-L-histidine | N-Mercaptoacetyl-L-histidine is an angiotensin-converting enzyme (ACE) inhibitor with a target pIC50 of 3.59 M.N-Mercaptoacetyl-L-histidine binds to the zinc-containing active site of ACE, which mediates conversion of angiotensin I to angiotensin II.N-Mercaptoacetyl-L-histidine can be used for the research of hypertension. | |||||||||||||||||||||
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References
- [1]. Waller CL, et al. Three-dimensional quantitative structure-activity relationship of angiotesin-converting enzyme and thermolysin inhibitors. II. A comparison of CoMFA models incorporating molecular orbital fields and desolvation free energies based on active-analog and complementary-receptor-field alignment rules. J Med Chem. 1993;36(16):2390-2403. [Content Brief]
Keywords
