6462-58-4
6462-58-4
Chemical Structure
Tamoxifen derivative-1
- CAS 番号: 6462-58-4
- Formula:C28H31NO2
- Molecular Weight:413.55
InChIKey: TZZSBHQJRVXWFX-DQSJHHFOSA-N
SMILES: CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(C=C3)OCCN4CCOCC4
Biological Activity: Tamoxifen derivative-1 is a derivative of Tamoxifen (HY-13757A) with reduced affinity for estrogen receptor (ER). Tamoxifen derivative-1 blocks estrogen-induced activity, inhibits estrogen-stimulated uterine growth, and exhibits uterotrophic activity in immature rats. Tamoxifen derivative-1 can be used in research related to breast cancer[1][2].
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Tamoxifen derivative-1 | Tamoxifen derivative-1 is a derivative of Tamoxifen (HY-13757A) with reduced affinity for estrogen receptor (ER). Tamoxifen derivative-1 blocks estrogen-induced activity, inhibits estrogen-stimulated uterine growth, and exhibits uterotrophic activity in immature rats. Tamoxifen derivative-1 can be used in research related to breast cancer. | |||||||||||||||||||||
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References
- [1]. Robertson DW, et al. Antiestrogen basicity--activity relationships: a comparison of the estrogen receptor binding and antiuterotrophic potencies of several analogues of (Z)-1,2-diphenyl-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-butene (tamoxifen, Nolvadex) having altered basicity. Journal of medicinal chemistry. 1982 Feb;25(2):167-71. [Content Brief]
- [2]. Dayan G, et al. Tamoxifen and raloxifene differ in their functional interactions with aspartate 351 of estrogen receptor alpha. Molecular pharmacology. 2006 Aug;70(2):579-88. [Content Brief]
Keywords
